The Hyderabad to Thoothukudi bus route covers approximately 1160 kms and takes about 17 hrs 47 mins. A total of 4 direct buses operated by 3 bus operators run on this route. The first bus departs at 09:00, and the last bus leaves at 14:50.
Major boarding points in Hyderabad include Ameerpet, Aramghar, Begumpet, Bharat Nagar, ESI, Erragadda, Gachibowli, Hydernagar, Jadcherla, KPHB, while common drop locations in Thoothukudi are New Bus Stand.
RTC and private operators such as Kallada Travels (Suresh Kallada) offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 2200 - INR 4500.00 depending on the bus type and features.



